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NOT YET RECRUITING
NCT05857241
NA

Therapeutic Fasting and Immune Aging

Sponsor: Centre Hospitalier Universitaire de Saint Etienne

View on ClinicalTrials.gov

Summary

Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity/adaptability of the lymphocyte repertoire. The consequences of immunosenescence are multiple, including increased susceptibility to infections and poorer vaccine responses.

Official title: Therapeutic Fasting and Immune Aging: A Pilot Study of Tolerance

Key Details

Gender

All

Age Range

65 Years - Any

Study Type

INTERVENTIONAL

Enrollment

20

Start Date

2025-04

Completion Date

2026-03

Last Updated

2025-04-08

Healthy Volunteers

No

Interventions

DIETARY_SUPPLEMENT

Fasting mimicking diet (FMD)

D1 will correspond to a "pre-fasting" phase, with about 800 kcal of intake (approximately 40% of normal caloric intake) from a mono-nutrient diet (fruit, rice or potato according to the patient's preferences). Then D2 and D3 will correspond to the days of actual fasting, with 200-350 kcal of intake (10-18% of normal caloric intake) in the form of 100 ml of broth or vegetable juice (with a teaspoon of linseed oil) three times a day, and vaccination will take place on D4, after returning to a normal diet. 2 to 3 liter of water or unsweetened drink per day is required.Laxatives (unsweetened) will be prescribed and can be taken as during the fasting period.

Locations (5)

EHPAD Claudinon

Le Chambon-Feugerolles, France

EHPAD Les Cèdres Malataverne

Malataverne, France

CHU de Saint-Etienne

Saint-Etienne, France

EHPAD de la Talaudière, la Rivière, la Croix de l'Horme

Saint-Etienne, France

EHPAD La M.R.L

Saint-Just-Saint-Rambert, France