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Therapeutic Fasting and Immune Aging
Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Summary
Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity/adaptability of the lymphocyte repertoire. The consequences of immunosenescence are multiple, including increased susceptibility to infections and poorer vaccine responses.
Official title: Therapeutic Fasting and Immune Aging: A Pilot Study of Tolerance
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-04
Completion Date
2026-03
Last Updated
2025-04-08
Healthy Volunteers
No
Conditions
Interventions
Fasting mimicking diet (FMD)
D1 will correspond to a "pre-fasting" phase, with about 800 kcal of intake (approximately 40% of normal caloric intake) from a mono-nutrient diet (fruit, rice or potato according to the patient's preferences). Then D2 and D3 will correspond to the days of actual fasting, with 200-350 kcal of intake (10-18% of normal caloric intake) in the form of 100 ml of broth or vegetable juice (with a teaspoon of linseed oil) three times a day, and vaccination will take place on D4, after returning to a normal diet. 2 to 3 liter of water or unsweetened drink per day is required.Laxatives (unsweetened) will be prescribed and can be taken as during the fasting period.
Locations (5)
EHPAD Claudinon
Le Chambon-Feugerolles, France
EHPAD Les Cèdres Malataverne
Malataverne, France
CHU de Saint-Etienne
Saint-Etienne, France
EHPAD de la Talaudière, la Rivière, la Croix de l'Horme
Saint-Etienne, France
EHPAD La M.R.L
Saint-Just-Saint-Rambert, France