Clinical Research Directory

Inclusion Criteria: 1. mTBI within the last 2 to 4 months according to the diagnostic criteria recommended by the WHO task force 2. age ≥ 18 years at the time of mTBI 3. Rivermead Post-Concussion Symptoms Questionnaire (RPQ) score ≥ 3 (moderate or severe problem) for subitem headache and a diagnosis of persistent PTH attributed to mTBI according to ICHD-3. Additionally, for study 2 and 3, subjects have to be stable on preventative headache medication. However, subjects are permitted to take ''as needed'' (PRN) medications throughout the study with documentation in a daily headache diary. Exclusion Criteria: 1. objective neurological findings and/or acute trauma CT scan indicating neurological disease or brain damage 2. previous mTBI within the last 2 years years leading to PCS lasting ≥ 3 months. Additionally, for study 2 and 3, 3. Pre-trauma headache frequency ≥ 10 days in average per month the last 3 months prior to mTBI. 4. past history of TMS therapy or TMS-related contraindications (pacemaker, epilepsy etc.).