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Low-Intensity Focused Ultrasound for Cocaine Use Disorder
Sponsor: University of Virginia
Summary
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings. Data analysis will serve to show if 1) LIFU is safe and effective and to 2) examine the effects of LIFU on dAI BOLD activity and craving in response to cocaine cue-exposure. The study will screen 60 individuals with Cocaine Use Disorder (CUD) to arrive at 30 enrolled subjects, based on a 2:1 screen/randomization ratio.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2023-03-24
Completion Date
2025-08-31
Last Updated
2026-05-28
Healthy Volunteers
Yes
Interventions
Low-Intensity Focused Ultrasound
Low-Intensity Focused Ultrasound administration to right dorsal anterior insula, in one of two sessions
Sham LIFU device
Sham LIFU device administered in one of two sessions
Locations (1)
UVA Center for Leading Edge Addiction Research
Charlottesville, Virginia, United States