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RECRUITING
NCT05857969
PHASE1

Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling

Sponsor: Florida International University

View on ClinicalTrials.gov

Summary

Functional precision medicine (FPM) is a relatively new approach to cancer therapy based on direct exposure of patient- isolated tumor cells to clinically approved drugs and integrates ex vivo drug sensitivity testing (DST) and genomic profiling to determine the optimal individualized therapy for cancer patients. In this study, we will enroll relapsed or refractory pediatric cancer patients with tissue available for DST and genomic profiling from the South Florida area, which is 69% Hispanic and 18% Black. Tumor cells collected from tissue taken during routine biopsy or surgery will be tested.

Official title: Adopting a Functional Precision Medicine Approach For Individualized Pediatric Cancer Treatments

Key Details

Gender

All

Age Range

1 Day - 21 Years

Study Type

INTERVENTIONAL

Enrollment

65

Start Date

2023-02-22

Completion Date

2028-12-31

Last Updated

2025-07-11

Healthy Volunteers

No

Interventions

DEVICE

Functional Precision Medicine

Ex Vivo Drug Sensitivity Testing + Genomic Tumor Profiling

Locations (1)

Nicklaus Children's Hospital

Miami, Florida, United States