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Ex Vivo Drug Sensitivity Testing and Multi-Omics Profiling
Sponsor: Florida International University
Summary
Functional precision medicine (FPM) is a relatively new approach to cancer therapy based on direct exposure of patient- isolated tumor cells to clinically approved drugs and integrates ex vivo drug sensitivity testing (DST) and genomic profiling to determine the optimal individualized therapy for cancer patients. In this study, we will enroll relapsed or refractory pediatric cancer patients with tissue available for DST and genomic profiling from the South Florida area, which is 69% Hispanic and 18% Black. Tumor cells collected from tissue taken during routine biopsy or surgery will be tested.
Official title: Adopting a Functional Precision Medicine Approach For Individualized Pediatric Cancer Treatments
Key Details
Gender
All
Age Range
1 Day - 21 Years
Study Type
INTERVENTIONAL
Enrollment
65
Start Date
2023-02-22
Completion Date
2028-12-31
Last Updated
2025-07-11
Healthy Volunteers
No
Conditions
Interventions
Functional Precision Medicine
Ex Vivo Drug Sensitivity Testing + Genomic Tumor Profiling
Locations (1)
Nicklaus Children's Hospital
Miami, Florida, United States