Inclusion Criteria:
1. Voluntarily sign an ICF and expect to complete the study procedures for follow-up examinations and treatment.
2. Aged 18 to 70 years (including cut-offs), regardless of gender.
3. Subject must be diagnosed with AML according to World Health Organization (WHO) criteria (2016).
4. The subject has received an allogeneic HSCT within 60-100 days, the percentage of malignant primitive cells in the bone marrow is \< 5% after HSCT and STR-PCR shows complete donor chimerism.
5. The subject has one of the following high-risk factors for relapse after allo-HSCT: (1) Failure to achieve remission after two courses of induction chemotherapy. (2) Prior history of Myelodysplastic Syndromes (MDS) or Myeloproliferative Neoplasm (MPN). (3) High leukocytes (≥100×10\^9/L) combined with Central Nervous System Leukemia (CNSL); (4) Positive Minimal Residual Disease (MRD) before HSCT; (5) Non-remission or disease progression prior to HSCT; (6) Subject with cytogenetic high-risk factors (except that who can be treated with targeted drugs).
6. The subject has recovered from the toxicity of the prior treatment, i.e., CTCAE toxicity grade \<2 (unless the abnormality is tumor-related).
7. ECOG score 0 to 1.
8. With appropriate organ function:
* Glutathione aminotransferase (AST) ≤ 3 times the upper limit of normal (ULN);
* Glutamic aminotransferase (ALT) ≤ 3 times ULN;
* Total bilirubin ≤ 1.5 times ULN, unless the patient has documented Gilbert syndrome. Patients with Gilbert-Meulengracht syndrome with total bilirubin ≤ 3.0 times ULN and direct bilirubin ≤ 1.5 times ULN may be included;
* Serum creatinine ≤ 1.5 times ULN or a creatinine clearance ≥ 60 ml/min;
* Hemoglobin ≥ 80 g/L or hemoglobin maintained at that level following transfusion;
* International Normalized Ratio (INR) ≤ 1.5 times ULN and Activated Partial Thromboplastin Time (APTT) ≤ 1.5 times ULN;
* Absolute neutrophil count (ANC) ≥ 1.5 x 10\^9/L.
* A platelet count ≥ 50 x 10\^9/L or a platelet count maintained at that level following a platelet transfusion;
* Left ventricular ejection fraction (LVEF) ≥ 45%.
9. Female patients with childbearing potential should have a negative pregnancy test during the screening period. Any male and female patients of childbearing potential must agree to use an effective contraception method for at least six months from the time that they sign the informed consent form until the end of the cell infusion. Female patients without childbearing potential (meeting at least 1 of the following criteria) is described below.
* Have undergone a hysterectomy or bilateral oophorectomy;
* Medically recognized as ovarian failure;
* Medically recognized as post-menopausal (at least 12 consecutive months of menopause without pathological or physiological cause).
Exclusion Criteria:
1. Subject is confirmed to have morphological relapse of leukemia or positive MRD after allo-HSCT.
2. Subject with extramedullary infiltration of leukemia.
3. Suffer from other malignancies within 5 years prior to screening, except adequately treated carcinoma in situ of the cervix, basal cell or squamous epithelial cell skin cancer, post-radical thyroid cancer, and post-radical ductal carcinoma in situ.
4. Has severe respiratory disease (previous or combined history of severe interstitial lung disease, severe chronic obstructive pulmonary disease, severe pulmonary insufficiency, symptomatic bronchospasm).
5. A previous history of a definite neurological or psychiatric disorder, including epilepsy or dementia.
6. Evidence of active central nervous system invasion or cranial neuropathy.
7. Patients with positive hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) and peripheral blood hepatitis B virus (HBV) DNA titration assay not within the normal reference range, positive hepatitis C virus (HCV) antibody and peripheral blood HCV RNA ,positive for human immunodeficiency virus (HIV), or positive for cytomegalovirus (CMV) DNA, or positive syphilis test.
8. Subject who is allergic to the excipients of RC1012 injection or other drugs recommended in the study protocol (e.g., tolimumab, etc.).
9. Serious cardiac disease, including but not limited to severe arrhythmia, unstable angina, massive heart attack, New York Heart Association class III or IV cardiac insufficiency, refractory hypertension.
10. Persons who have previously received an organ transplant or are preparing to receive an organ transplant (except for HSCT).
11. Subject who has received other maintenance therapy drugs after HSCT or who wish to receive other maintenance therapy.
12. Subject with the presence of acute GvHD of degree III to IV or extensive chronic GvHD.
13. Active neurological autoimmune or inflammatory diseases (e.g. Guillain-Barre Syndrome (GBS), Amyotrophic lateral sclerosis (ALS)).
14. Clinically significant active cerebrovascular disease (e.g. cerebral oedema, Posterior Reversible Encephalopathy Syndrome (PRES)).
15. Subject with a life expectancy of less than 3 months.
16. Subject has been involved in other clinical studies within 3 months prior to screening.
17. Subject , in the judgement of the investigator and/or clinical criteria, is contraindicated to any study procedure or have other medical conditions that may place them at unacceptable risk.
