Clinical Research Directory

Inclusion Criteria: * Aged 60-80 years old * Have been taking antihypertensive drugs for more than 2 weeks * The average SBP and/or DBP of 7-day home blood pressure monitoring ≥135/85 mmHg * Willing to participate, adhere to follow-up, and sign the written informed consent form Exclusion Criteria: * Arm circumference too large or too small (less than 18 cm or greater than 42 cm) to fit the cuff in case of inaccurate measurement * Invalid home blood pressure monitoring. The valid home blood pressure monitoring requires consecutive measurements for at least 3 days, with not less than 1 measurement in the morning and evening, respectively. * Office blood pressure indicates stage 3 clinic hypertension (≥180/110 mmHg) during the screening period * Suspected or known secondary hypertension * Orthostatic hypotension, defined as a decrease in systolic blood pressure greater than 20 mmHg or diastolic blood pressure greater than 10 mmHg within 3 minutes when position is changed from sitting to standing * eGFR\<30 ml/min/1.73m2 or end-stage renal disease * Cardiovascular events occured within the past 3 months, such as myocardial infarction, stroke, acute heart failure, hospitalization for unstable angina, undergoing coronary artery revascularization or bypass grafting * Abnormal liver function (ALT/AST/total bilirubin more than 2 times the upper limit of normal value) * Severe somatic disease with a life expectancy of less than 3 years, or diagnosed with cancer within the past 2 years requiring treatment * Doctors deem that the participation would do harm to the patients or the patients would have poor compliance.