Clinical Research Directory

Inclusion Criteria: * Male or female \> 40 years of age * Informed consent * At least two additional risk factors for Heart Failure (HF): * Coronary artery disease (either a previous documented type 1 myocardial infarction or coronary artery bypass grafting or percutaneous coronary intervention or documented stenosis or an epicardial coronary artery (50% left main stem or \>70% left anterior descending, circumflex or right coronary artery)). * Diabetes type 1 or 2. * Persistent or permanent atrial fibrillation. * Previous ischemic or embolic stroke. * Peripheral artery disease (previous surgical or percutaneous revascularization or documented stenosis \>50% of major peripheral arterial vessel. * Chronic kidney disease (defined as an estimated glomerular filtration rate (eGFR)\<60 milliliters per minute (mL/min)/1.73m2 or eGFR 60-90 mL/min/1.73m2 and urine albumin-creatinine ration (UACR) \>300mg/g). * Regular loop diuretic use for \>30 days within 12 months prior to consent. * Chronic obstructive pulmonary disease (COPD) evidenced by one of the following: Pulmonary Function Test (PFT) showing airway obstruction, diagnosis of respiratory physician, CT scan reporting presence of emphysema, or treatment with national guidance advocated COPD therapy. Exclusion Criteria: * Inability to give informed consent (e.g. due to significant cognitive impairment). * Previous diagnosis of heart failure. This is any diagnosis of heart failure with any ejection fraction of any cause. * Renal replacement therapy. * Anyone who, in the investigator's opinion, is not suitable to participate in the trial for other reasons e.g., a diagnosis which may compromise survival over the study period.