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RECRUITING
NCT05861089

Rest PETCO2 As a Predictor of Post-operative Complications

Sponsor: St. Anne's University Hospital Brno, Czech Republic

View on ClinicalTrials.gov

Summary

Cardiopulmonary exercise testing (CPET) is considered to be a golden standard in preoperative risk assessment and stratification of high risk patients scheduled for major surgery. However, not all of the patients requiring surgery are willing or able to complete this type of testing. Vascular surgery patients are predominantly elderly people, with significant comorbidity and high degree of frailty and often can not undergo CPET. In recent years, new parameters with similar prognostic value as standard CPET parameters were studied. Specifically, the partial pressure of end-tidal carbon dioxide (PETCO2) at rest has been shown to have the same prognostic value as ventilatory efficiency. We hypothesized low PETCO2 at rest will be associated with the development of pulmonary and cardiovascular post-operative complications in patients after major vascular surgery. Accordingly, our aim is to compare PETCO2 measured at rest before surgery in patients who develop post-operative complications and in those who do not.

Official title: Rest PETCO2 As a Predictor of Post-operative Complications in Patient Undergoing Major Vascular Surgery

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

130

Start Date

2023-06-01

Completion Date

2026-01-31

Last Updated

2024-11-20

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

end-tidal CO2 measurement

Measurements will take place day before surgery, under resting conditions (while sitting in a quiet room with no disruptions) using the Capnography monitor from Nonin Medical (breath by breath data will be recorded and analyzed). Patients will be allowed to get used to the nasal cannula for the first two minutes. Mean end-tidal CO2 value will then be calculated from the following two minutes of spontaneous breathing.

Locations (1)

St. Anne's University Hospital in Brno

Brno, Czech Republic, Czechia