Clinical Research Directory

Inclusion Criteria: Main Outcome: * Age \>22. * Patients with a history of non-muscle invasive bladder cancer (any risk group, any intravesical adjuvant treatment received) over the last 3 months to 2 years, initial or recurrent, undergoing regular cystoscopic surveillance. The criteria for cystoscope FU schedule has been already described in Methods following EAU 2022 Guidelines´ recommendations and related to initial NMIBC risk grouping. * Patient must be able to provide at least 10 ml of urine. * Additional 10 ml of urine needs to be collected for cytology. * Patients must be able to provide informed consent 2.- Subgroup analysis (secondary Objective 1): * Age \>22 * Patients with a history of primary non-muscle invasive bladder cancer with presence of CIS over the last 3 months to 3 years, and previously treated with BCG undergoing regular cystoscopic surveillance. * Patient must be able to provide at least 10 ml of urine. * Additional 10 ml of urine needs to be collected for cytology. * Patients must be able to provide informed consent. 3.- Subgroup analysis (secondary Objective 2): * Age \>22 * Patients included in both previous groups, having a positive Uromonitor® test and a negative cystoscopy to be followed by two years as previously described depending on initial NMIBC risk group. The rest of the patients will also be followed 2 years to detect later recurrences/progression figures. Exclusion Criteria: * Patients who are unable to provide the minimum amount of urine needed to perform one test. * Patients planning to undergo radical cystectomy or chemotherapy, radiation for UC * Patients at risk for non-definitive information derived from the cystoscope due to different conditions: * Not possible to ascertain informative cystoscope due to intolerance to the procedure * Presence of bladder stone * Presence of entero-vesical fistulae * Presence of vesico-vaginal fistulae * Non informative cystoscope due to macroscopic haematuria or cloudy urine * Other conditions avoiding a clear tumour rule-out cystoscope