Clinical Research Directory

Inclusion Criteria: 1. Admitted to the hospital for acute heart failure (diagnosed by dyspnea at rest and pulmonary congestion on chest X-ray or lung ultrasound) more than 72 hours prior to enrolment. 2. All measures within 24 hours prior to enrolment of systolic blood pressure ≥ 100 mmHg, and of heart rate ≥ 60 bpm. 3. The last measurement during the hospital admission prior to enrolment of serum potassium ≤ 5.0 mEq/L (mmol/L). 4. The last measuremet during the hospital admission prior to enrolment of NT-proBNP \> 1,500 pg/mL 5. At admission and at the time of enrolment being prescribed: (1) none to \< ½ the optimal dose (per the protocol) of renin angiotensin system inhibitor (RASi) - angiotensin converting enzyme inhibitor (ACEi), angiotensin receptor blocker (ARB), or angiotensin receptor-neprilysin inhibitor (ARNI), AND (2) none to \< ½ the optimal dose of beta-blocker (BB), AND (3) none to ≤ ½ the optimal dose of mineralocorticoid receptor antagonist (MRA). 6. Written informed consent to participate in the study. Exclusion Criteria: 1. Age \< 18 2. Myocardial infarction, unstable angina or cardiac surgery, or percutaneous transluminal coronary intervention (PTCI), within 1 month prior to enrolment. 3. Presence at enrolment of any severe valvular stenosis or regurgitation in need of surgical correction. 4. Last measurement during the hospital admission prior to enrollment of eGFR \< 30 mL/min/1.73m2 or history of dialysis. 5. Currently enrolled in a clinical study that mandates a schedule of follow-up visits for heart failure, or particular assessments or treatment for heart failure.