Clinical Research Directory

Inclusion Criteria: Patients with chronic liver disease: Patients over 18 years of age Patients affiliated with a social security plan or entitled to receive benefits Patients with chronic liver disease or cirrhosis whose diagnosis is based on one or more of the following * Liver biopsy showing chronic liver disease or cirrhosis * Liver elastography by Fibroscan® assessing the elasticity of the liver at more than 10 kpa * Combination of clinical, biological and imaging criteria characteristic of chronic liver disease (signs of portal hypertension, liver failure and liver dysmorphia in a patient with at least one risk factor for chronic liver disease) Controls without liver disease Patients 18 years of age with no known liver disease Patients who have had blood drawn in the hospital prior to surgery (pre-operative work-up as part of the care process). Exclusion Criteria: Common non-inclusion criteria for patients with chronic liver disease and controls without liver disease will be as follows: * Pregnant or lactating women * Protected populations: persons under guardianship, under curatorship or safeguard of justice * Patient under AME * Patient who has not signed a consent form * Recent surgery before the blood test (\< 2 weeks) * Transfusion of blood products (packed red blood cells, platelet concentrates, fresh frozen plasma, etc.) recently (\< 2 weeks) * Use of medication that interferes with hemostasis * Active extra-hepatic cancer or cancer less than 5 years old * Organ transplantation (liver, kidney, lung, heart)