Clinical Research Directory

Inclusion Criteria: * Age \>= 50 years, or age within 10 years of first degree relative with cancer at age of diagnosis (as long as age is \>= 18) * Have a strong family history of cancer ( \>= 2 first-degree relatives with cancer, one first and second degree relative with cancer in one lineage (side of family), or at least three first or second degree relatives with cancer in one lineage (side of the family). Non-melanoma skin cancer excluded from family history eligibility * Have a family history of early-onset cancer (age \>40) in at least one first-degree relative * Willing to have 50 mL of blood (approximately 3.5 tablespoons) drawn (40 ml if germline testing already performed) * Able to undergo MRI (no implants, metal, or claustrophobia that would preclude MRI) * Any cancer diagnosis within past 5 years, excluding non-melanoma skin cancer * Positron emission tomography/computed tomography (PET/CT) or other whole body imaging modality (including combination of CT chest and abdomen) within 3 years * No signs/symptoms of possible cancer (e.g. hemoptysis, breast mass, blood per rectum, unexplained weight loss) * Willing to undergo standard of care genetic counseling and germline testing, or has already undergone genetic counseling and germline testing * Documented informed consent of the participant Exclusion Criteria: * Unable to provide informed consent * Contraindications to MRI (implants, metal, or claustrophobia that would preclude MRI)