Clinical Research Directory

Biomarkers in Patients With Metastatic Breast Cancer

Sponsor: Tunisian Association for Immuno-oncology Research

Summary

In order to allow Tunisian patients with breast cancer to access immunotherapies, and innovative treatments to extend life expectancy of patients with breast cancer with a poor prognosis, it is important to study the epidemiological profile of Tunisian cancers breast, in terms of PD-L1 expression, tumor mutational burden (TMB), microsatellite instability status (MSI) and rate of TILs, in metastatic and locally advanced cases, in Tunis, over a one-year follow-up period. It is also important to study other inflammatory and tumor biomarkers which would have a prognostic or even therapeutic value: * serum dosage of LDH (lactate dehydrogenase) * IL-6 (interleukin 6) * CRP (C-reactive protein) * absolute count of lymphocytes (CLA) and eosinophils * quantification of circulating tumor DNA before treatment and under treatment. The primary objective id to identify the epidemiological profile of the biological signature (PD-L1 / TMB / MSI/HRD/ TILs) of patients with locally advanced or metastatic breast carcinoma before and during the systemic treatment.

Key Details

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Interventions