Clinical Research Directory

Inclusion Criteria: 1. Bilateral CRSwNP with prior treatment with systemic corticosteroids (SCS), and/or contraindicate to or intolerance to SCS, and/or with prior surgery to nasal polyps 2. Bilateral NPS of ≥5 with a minimum score of 2 in each nasal cavity at screening and at baseline. 3. Ongoing symptoms of nasal congestion/obstruction(NCS score of 2 or 3 at screening and at baseline). 4. Recorded use of intranasal corticosteroids for at least 4 weeks before screening Exclusion Criteria: 1. Insufficient washout time for drugs that have an impact on the evaluation of efficacy and safety。 2. Concurrent disease that may interfere with the evaluation of safety and efficacy in subjects, or affect the risk- benefit evaluation of subjects. eg. specific ongoing nasal diseases, severe asthma, active infection, Severe cardiovascular disease, Severe laboratory test abnormalities. 3. Other.