Clinical Research Directory

Inclusion Criteria: * 18 years or older. * Capable of providing written and oral informed consent. * Presumed perihilar cholangiocarcinoma. * Biliary obstruction in the future liver remnant. * Drainage naïve patients: total bilirubin \>50 umol/L * Patients with previous endobiliary drainage procedures: persistently rising total bilirubin \>50 umol/L (i.e. no stent placed or insufficient draining stent) or persistent biliary dilatation in the future liver remnant on imaging (i.e. previous stent placed in contralateral side of the liver). Exclusion Criteria: * Incompletely recovered from any side effects of previous biliary drainage procedures. Patients are required to be off antibiotic treatment for at least 5 days. * Any contra-indication for major liver surgery (e.g. ECOG/WHO score ≥3). * Technical contra-indications for endobiliary drainage (e.g. previous gastrojejunostomy). * Distance between stricture and sphincter less than 2 cm. * Refusal to provide informed consent.