Clinical Research Directory

Inclusion Criteria: * Age ≥ 16 * Non-metastatic/oligo-metastatic (up to 3 lesions from 2 sites predicted to be radically treatable) - locally advanced or locally recurrent disease involving the posterior or lateral components of the pelvis and predicted to be resectable but with close margins from imaging as determined by a specialist MDT (sMDT) * Colorectal sMDT review with experience in pelvic exenteration, which has proposed IntrOperative Electron Radiotherapy (IOERT) as an option for treatment * Patient suitable for IOERT as component of treatment in the view of the responsible Clinical Oncologist * Performance status ≤1 as defined by the Eastern Cooperative Oncology Group (ECOG) * Deemed medically fit for surgery * Written informed consent Exclusion Criteria: * Unresectable disease/likelihood of R2 resection * sMDT determined excess prior radiotherapy within IOERT target zone * Women who are pregnant or breastfeeding * Participation within an interventional clinical trial within 3 months of the point of registration within ELECTRA