Clinical Research Directory

Inclusion Criteria: * Small bowel obstruction diagnosed by radiographic study; and * Abdominal pain on admission. * Nothing per mouth diet. * The ability to give appropriate consent or have an appropriate representative available to do so. Exclusion Criteria: * Known liver failure or cirrhosis. * Acetaminophen toxicity on admission. * Known acetaminophen allergy. * Alcohol intoxication on admission. * History of substance abuse. * Creatinine clearance \< 30 (or Creatinine level \> 2). * Liver transplant recipients. * Ileus on admission. * Admitted for surgical intervention for SBO. * Admitted for venting Gastric tube placement. * On chronic opioid therapy (defined as use of opioid on daily or near daily basis within previous 45 days (both long acting and short acting). * Presentation without abdominal pain on admission. * Already hospitalized for other reasons and develop SBO while at the hospital. * Pregnant women. * Unable to provide informed consent.