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Effects of Vitamin D Status and Multiple Mega-dose Supplementation on Health Care Disparities in Perioperative Patients With Hepatocellular Carcinoma Receiving Hepatectomy
Sponsor: Taoyuan General Hospital
Summary
High concentrations of parathyroid hormone (PTH) are common in patients with hepatocellular carcinoma (HCC). This study is aimed to investigate effects of vitamin D status and its multiple mega-dosage supplementation on PTH and clinical outcomes in HCC patients before and after hepatectomy. It's a single-center, prospective, parallel, double-blind, placebo-controlled study for 120 eligible subjects. The subjects will receive consecutively 3-day intervention treatments from 7th day before surgery. 30-day postoperative mortality, postoperative complications, and laboratory data will be evaluated.
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2023-06-09
Completion Date
2027-12-31
Last Updated
2023-06-06
Healthy Volunteers
No
Interventions
Vitamin D
Oral supplementation of 576,000IU/day vitamin D3 in 3 consecutive days
Placebo
Oral supplementation of placebo in 3 consecutive days.