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Multi-parametric Imaging in Personalized Radiotherapy
Sponsor: CNAO National Center of Oncological Hadrontherapy
Summary
The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers which, integrated with advanced mathematical models, will allow predicting treatment outcome on a multi-scale basis.
Official title: A Technical Framework for Combining Multi-parametric Imaging With Advanced Modelling in Personalized Radiotherapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
35
Start Date
2022-04-19
Completion Date
2025-08-18
Last Updated
2024-08-21
Healthy Volunteers
No
Conditions
Interventions
diffusion MRI sequences
Diffusion MRI sequences will be optimized to derive more accurate estimates of microstructure and microvasculature of tumour and healthy organs: multiple b-values will be acquired and advanced diffusivity models considered. MRI sequences to derive tumour hypoxia (i.e. indicative of radioresistance) will be also considered along with MR spectroscopy to evaluate tumour microenvironment.
Locations (1)
CNAO
Pavia, Pv, Italy