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Allopurinol Improves Heart Function in African Americans With Resistant Hypertension
Sponsor: VA Office of Research and Development
Summary
African American adults in the United States have the highest prevalence rate of high blood pressure (hypertension) and heart failure in the world. African Americans with treatment resistant hypertension have higher levels of the enzyme - xanthine oxidase compared to Caucasians. This trial will test if administration of the xanthine oxidase inhibitor - Allopurinol (commonly used in the treatment of gout), given over a period of 8 weeks, will improve heart function, exercise ability and quality of life in African American Veterans with resistant hypertension.
Official title: Allopurinol Improves Diastolic Function in African Americans With Resistant Hypertension
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-09-30
Completion Date
2026-05-31
Last Updated
2026-01-22
Healthy Volunteers
No
Interventions
Allopurinol
Single arm of Allopurinol treatment for 300mg/daily for 4 weeks then may be increased to 600mg/daily for an additional 4 weeks.
Locations (1)
Birmingham VA Medical Center, Birmingham, AL
Birmingham, Alabama, United States