Clinical Research Directory

Inclusion Criteria for symptomatic patient cohort * Patients must be 18 years of age or older, able to provide written informed consent, and ability to lie still for PET scanning. * Suspected knee prosthetic infection at least 2 months after original prosthesis placement and who are scheduled to undergo surgery debridement/removal based on the clinical assessment of the referring surgeon. * Elevated CRP and ESR Exclusion Criteria for symptomatic patient cohort: * Undergoing current or recent antimicrobial therapy (within 1 month) * Significant comorbidity such as renal failure, septic shock, uncontrolled diabetes * Other clinically likely site of infection Inclusion Criteria for asymptomatic cohort: * Patients must be 18 years of age or older, able to provide written informed consent and ability to lie still for PET scanning * Knee prosthesis in situ without complications for 6 months or longer Exclusion Criteria for asymptomatic cohort: * Clinical or laboratory suspicion of knee prosthesis infection * Recent (within 3 months) or current treatment for infected knee prosthesis * Significant comorbidity such as renal failure, septic shock, uncontrolled diabetes