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RECRUITING
NCT05889741
PHASE2

Combining Stellate Ganglion Block With Prolonged Exposure for PTSD

Sponsor: The University of Texas Health Science Center at San Antonio

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to compare the combination of Massed Prolonged Exposure (PE); a behavioral therapy for PTSD) and a stellate ganglion block (SGB; an injection of a local anesthetic into the front of the neck) with Massed Prolonged Exposure and a sham injection in a sample of military service members or retirees with PTSD. The main questions it aims to answer are: (1) Does the addition of an SGB improve treatment outcomes associated with Massed PE and (2) Do differences in psychophysiological arousal during the exposure portion of treatment help explain treatment outcomes for PTSD. Participants will receive ten 90-minute session of Massed PE. Between the first and second Massed PE sessions, half of the participants will receive a SGB, and half will receive a sham SGB.

Official title: Combining Stellate Ganglion Block With Prolonged Exposure for PTSD: A Randomized Clinical Trial

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

140

Start Date

2024-02-26

Completion Date

2027-08-31

Last Updated

2025-09-04

Healthy Volunteers

Yes

Interventions

DRUG

Ropivacaine injection

6.5cc of Ropivacaine hydrochloride (HCl) 0.5%, one time into the stellate ganglion

DRUG

Normal saline

6.5cc of Normal Saline one time into the stellate ganglion.

Locations (2)

Carl R. Darnall Army Medical Center

Fort Hood, Texas, United States

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States