Clinical Research Directory

Inclusion Criteria: * Individuals who are nonsmokers * Healthy overweight/ obese man or woman between 25 and 65 years of age * Blood pressure 120-160 mmHg systolic or 80-100 mm/Hg diastolic at screening visit * Fasting blood glucose concentration between 100 mg/dL and 125 mg/dL at screening visit (value range indicate prediabetes, by finger prick and/or venous blood sampling) * Have no clinical evidence/history of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease Exclusion Criteria: * Smoker * Vegetarian * Men and women who have fasting blood glucose concentration \<100 or \>125 mg/dL at screening visit * Uncontrolled blood pressure ≥140 mmHg (systolic)/ ≥ 90 mmHg (diastolic) * Over the counter supplements (e.g. fiber supplements, probiotics and/or prebiotics, antioxidants, anti-inflammation) * Dietary supplements like (garlic, fish oil), glutamine supplements, grape seed extract, L-citrulline/arginine * Cholesterol-lowering medications, anticoagulants, blood pressure-lowering medications,) and/or taking prescription medications that may interfere with study procedures or endpoints (e.g. gastrointestinal medications, antibiotics) within the last 30 days * Have cancer other than non-melanoma skin cancer in previous 5 years * Taking unstable dose of hormonal contraceptive and/or a stable dose less than 6 months * Planning to become pregnant, pregnant and/or breast-feeding * Excessive exerciser or a trained athlete * Drink excessive amount of coffee/tea (\> 5 cups per day) * Donated blood within last 3 months * Have allergies/intolerances to foods consumed in the study * Currently eat \> 2 servings of watermelons per day * Actively losing weight/ trying to lose weight (unstable body weight fluctuations of \> 11 lbs in 3 months) * Addicted to drugs or alcohol * Have significant psychiatric or neurological disturbances that may interfere with the ability to follow the study protocol