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Multiple Objective Particle Swarm Optimization Postural Instability Gait Disorder
Sponsor: University of Minnesota
Summary
Sixty patients will be enrolled in this study who are treated for Parkinson's disease (PD) with bilateral deep brain stimulation of subthalamic nucleus (STN) or globus pallidus (GP), who have a pre- operative 7 Tesla MRI including diffusion tensor imaging for tractography and a postoperative head CT for electrode localization, and in whom at least 3 months have passed since activation of their neurostimulators, for stabilization of clinical stimulator settings. Using their MRI and CT, the investigators will construct patient-specific models of electrical current spread to neuroanatomical tar- gets surrounding the electrode. Then applying nonlinear (particle swarm) optimization, patient- specific stimulator settings will be designed to maximally or minimally activate specific path- ways. In STN DBS: pedunculopallidal vs. pallidopeduncular pathways. In GP DBS: pallidopeduncular pathways at its origin in GP pars interna (GPi) vs. inhibitory afferents to GPi (from GP pars externa GPe). All stimulation falls within the the FDA-approved range for DBS for PD.
Key Details
Gender
All
Age Range
18 Years - 89 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2021-05-25
Completion Date
2027-07-15
Last Updated
2025-09-26
Healthy Volunteers
No
Conditions
Interventions
Deep Brain Stimulation, STN
DBS of the STN, within FDA-approved limits and labeling, for symptoms of PD
GP Deep Brain Stimulation
PD with GP DBS, within FDA-approved limits and labeling, for symptoms of PD.
Locations (1)
University of Minnesota
Minneapolis, Minnesota, United States