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Prospective Cohort for Tumor Bed Boost Radiotherapy in HER2 Positive Breast Cancer
Sponsor: Samsung Medical Center
Summary
The purpose of this study is to analyze treatment outcomes related to tumor bed boost of postoperative radiation therapy in patient with HER2+ breast cancer who underwent breast conserving surgery. The main questions it aims to answer are: * 7-year ipsilateral breast tumor recurrence * 7-year disease-free survival * 7-year locoregional recurrence * 7-year overall survival * Adverse events of radiation therapy Participants will be assessed by multi-dimensional methods after radiation therapy: * Assessment for the disease status (disease-free or recurrence) including physical and radiologic examination * Assessment for the adverse events according to CTCAE version 5.0
Key Details
Gender
FEMALE
Age Range
19 Years - Any
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2022-11-29
Completion Date
2032-11-29
Last Updated
2025-06-29
Healthy Volunteers
No
Conditions
Interventions
Whole breast irradiation +/- tumor bed boost
Postoperative whole breast irradiation (3D-conformal radiation therapy or IMRT) with or without tumor bed boost (sequential or simultaneous integrated boost)
Locations (1)
Samsung Medical Center
Seoul, South Korea