Clinical Research Directory

Inclusion Criteria: * Man or woman older than 18 years oldRight-handed * Signed Informed Consent form * Subject affiliated to or beneficiary from a French social security regime * Inpatient or outpatient at the Adult Psychiatry Service * Diagnosis of Major Depressive Disorder according to the 5th edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria and confirmation by the MINI Structured Clinical Interview * MADRS score ≥ 18 * Beck Scale for Suicide Ideation (BSS) score ≥8 * Under antidepressant treatment * Absence of severe progressive neurologic and/or somatic pathologies (specially tumors, degenerative diseases) Exclusion Criteria: * tDCS contraindication * Younger than 18 years old * Left-handed * under mood stabilizer and/or antiepileptic * treated by ECT or rTMS or tDCS for the current eposide * Subject under measure of protection or guardianship of justice * Presence of other psychiatric pahtologies * Subject beneficiary from a legal protection regime * Subject unlikely to cooperate or low cooperation stated by investigator * Subject not covered by social security * Pregnant woman * Subject being in the exclusion period of another study or provided for by the "National Volunteer File"