Clinical Research Directory

Inclusion Criteria: * 8-18 years of age * History of non-neurogenic overactive bladder or detrusor overactivity and/or urinary incontinence (ICD 10 codes respectively - N32.81, N39.498) * Obtained legally effective informed consent and Health Insurance Portability and Accountability Act (HIPPA) authorization from the participant or the participant's parent/legal guardian * Minor participant is willing and able to provide assent (as applicable) * Vancouver Dysfunctional Elimination Syndrome\[15\] score of ≥11 and a positive modified bother score within 30 days of consent Exclusion Criteria: * Known or apparent untreated anatomical abnormality of lower urinary tract (i.e. untreated ureterocele) * Known neurogenic bladder (e.g., spina bifida, history of spinal cord injury, tethered cord) * Nerve damage that may impact pelvic floor function * History of chemodenervation of the bladder (e.g., via intravesical instillation or intradetrusor injection of botulinum toxin) * Active, untreated UTI at the time of enrollment (UTI undergoing active treatment is allowable) * Current or previous pregnancy at screening or planned pregnancy during the duration of the study, for females of childbearing potential * Any condition that, in the judgment of the investigator or treating clinician, precludes participation because it could affect participant safety