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Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men
Sponsor: Tanta University
Summary
Bacterial sexually transmitted infections (STIs) have been steadily increasing in gay, bisexual, and other men who have sex with men (MSM) over the past 2 decades. While that trend started prior to the introduction of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) in 2012, HIV PrEP has been associated with increases in sexual contacts and decreases in condom use with an resultant acceleration in the increase of bacterial STIs such as gonorrhea, syphilis, and chlamydia.
Official title: Clinical Study to Investigate the Effect of Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men
Key Details
Gender
MALE
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2023-06-20
Completion Date
2028-06-20
Last Updated
2023-06-12
Healthy Volunteers
No
Conditions
Interventions
Doxycyclin
Doxycycline is a moderate-spectrum, second-generation tetracycline that is generally well tolerated
Pentoxifylline
Pentoxifylline is a vasoactive agent that improves the flow of blood by reducing its viscosity
Nitazoxanide 500Mg Oral Tablet
Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral medication that is used in medicine for the treatment of various helminthic, protozoal, and viral infections