Clinical Research Directory
Browse clinical research sites, groups, and studies.
Polyethylene-glycol Assisted Nerve Repair in Phalloplasty
Sponsor: Vanderbilt University Medical Center
Summary
Phalloplasty, a genitourinary surgery for transmasculine patients, reconstructs a neophallus using tissue transferred from other parts of the body to the groin. However, this technique fails to provide adequate sensation, causing regret and persistent dysphoria. Peripheral nerve regeneration is the greatest barrier to sensory recovery, given the slow rate of regrowth coupled with the negative effects of axonal degeneration. Topical application of polyethylene glycol (PEG) fuses severed axonal membranes, restoring the nerve's immediate ability to conduct electrical signals across the repair site. The investigators hypothesize that utilizing PEG in phalloplasties will significantly improve neophallus sensation and postoperative quality of life.
Official title: Nerve Repair Using Hydrophilic Polymers to Improve Tactile and Erogenous Neophallus Sensation
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2023-08-01
Completion Date
2029-12-01
Last Updated
2025-10-20
Healthy Volunteers
No
Conditions
Interventions
Polyethylene Glycol 3350
Topical irrigation with approximately 2 ccs of a 190 mM solution of 50% PEG 3.35 kD in sterile water
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States