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Nevoid Basal Cell Carcinomas in Gorlin Syndrome
Sponsor: Oslo University Hospital
Summary
The overall aim of the project is to gain knowledge about the expected course of nevoid basal cell carcinomas and the usefulness of dermatoscopy in young individuals with Gorlin syndrome. Clinical experience and some case-reports suggest that nevoid basal cell carcinomas have an indolent course with slow growth and that they can sometimes regress. However, no systematic research has previously been performed. Increased knowledge about nevoid basal cell carcinomas and the use of dermatoscopy could be of great clinical value in the follow-up and treatment of individuals with nevoid basal cell carcinoma syndrome.
Official title: Nevoid Basal Cell Carcinomas in Young People With Gorlin Syndrome
Key Details
Gender
All
Age Range
6 Years - 17 Years
Study Type
OBSERVATIONAL
Enrollment
7
Start Date
2023-06-01
Completion Date
2026-07-03
Last Updated
2026-10-09
Healthy Volunteers
No
Conditions
Interventions
Active surveillance
Skin lesions clinically compatible with nevoid basal cell carcinomas are documented with measurements, clinical description, clinical photos and dermatoscopy photos every eight months for two years. Three representative skin lesions are selected at the first visit to be removed by skin biopsy at the end of the observation period (two years) for histopathological analyses. If a nevoid basal cell carcinoma shows a certain increases in size (according to pre-specified criteria of the study protocol), ulcerates, gets unevenly demarcated or give functional complaints during the observation period, the skin lesion will be excised.
Locations (1)
Oslo University Hospital
Oslo, Oslo, Norway