Clinical Research Directory

Immune Function and the Progression to T1D

Sponsor: University of Florida

Summary

To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.

Official title: Immune Function and the Progression to Type 1 Diabetes:

Key Details

Conditions

Interventions

Locations (3)