Clinical Research Directory

Inclusion Criteria: * Diagnosis of Fanconi disease confirmed by chromosome breakage test and/or genetic analysis * aged between 6 months and 60 years * with severe pancytopenia (2 of the following criteria: reticulocytes \< 60 G/L, PNN \< 0.5 G/L and/or platelets \< 20 G/L or patients with more than 6 transfusions in the last 12 months) * with clonal progression (poor prognostic cytogenetics, myelodysplastic syndrome or acute leukaemia) * with an unaffected haploidentical donor * having signed the consent after having read the information note, consent of both parents for minors, of the guardian for patients under guardianship * having a social security scheme (beneficiary or entitled person) Exclusion Criteria: * with an unaffected matched related or HLA 10/10 matched unrelated donnor * under guardianship