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AMP SCZ® Observational Study: PREDICT-DPACC
Sponsor: Brigham and Women's Hospital
Summary
The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) is a large international collaboration to develop algorithms using a set of clinical and cognitive assessments, multi-modal biomarkers, and clinical endpoints that can be used to predict the trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the testing of pharmacological interventions for CHR individuals in need. The goal is to accurately predict which individuals are likely to remit, experience an acute psychotic episode, or have intermediate outcomes that feature persistent attenuated psychotic and/or mood symptoms along with functional impairment. The prediction algorithms will have the potential to serve as early indicators of treatment efficacy in CHR persons. The AMP SCZ research program is made up of the Psychosis Risk Evaluation, Data Integration, and Computational Technologies - Data Processing, Analysis and Coordination Center (PREDICT-DPACC) and two clinical research networks, the Psychosis-Risk Outcomes Network (ProNET) and the Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT) networks. The two clinical research networks will recruit a large cohort of CHR young people aged 12-30 years (n=1,977) and healthy control (HC) participants (n=640) across 42 participating investigative sites from 13 countries. CHR participants will complete screening, baseline assessments and a battery of follow-up assessments across 18 - 24 months. HC participants will complete screening and baseline assessments and a subset (5 per site) will complete month 2, 12 and 24 visits.
Official title: Accelerating Medicines Partnership® Schizophrenia Observational Study: Psychosis Risk Evaluation, Data Integration, and Computational Technologies -Data Processing, Analysis, and Coordination Center and Coordination Center
Key Details
Gender
All
Age Range
12 Years - 30 Years
Study Type
OBSERVATIONAL
Enrollment
2617
Start Date
2022-06-02
Completion Date
2027-04-30
Last Updated
2025-10-31
Healthy Volunteers
Yes
Locations (42)
University of California Irvine
Irvine, California, United States
University of California Los Angeles
Los Angeles, California, United States
University of California San Diego
San Diego, California, United States
University of California San Francisco
San Francisco, California, United States
Hartford Healthcare
Hartford, Connecticut, United States
Yale University/Connecticut Mental Health Center
New Haven, Connecticut, United States
University of Georgia
Athens, Georgia, United States
Northwestern University
Evanston, Illinois, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Washington University
St Louis, Missouri, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Northwell Health
Queens, New York, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
University of Oregon
Eugene, Oregon, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Temple University
Philadelphia, Pennsylvania, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
HEP and co-located Headspace Adelaide
Adelaide, South Australia, Australia
Headspace, Craigieburn
Craigieburn, Victoria, Australia
Headspace, Glenroy
Glenroy, Victoria, Australia
Headspace Melton
Melton South, Victoria, Australia
Orygen Specialist Programs, Melbourne
Parkville, Victoria, Australia
Headspace, Sunshine
Sunshine, Victoria, Australia
Headspace, Werribee
Werribee, Victoria, Australia
University of Calgary
Calgary, Alberta, Canada
McGill University
Montreal, Quebec, Canada
Hospital Clínico Universidad de Chile (HCUCH)
Santiago, Santiago Metropolitan, Chile
Shanghai Jiao Tong University
Shanghai, China
Copenhagen Research Center for Mental Health (CORE)
Copenhagen, Denmark
Klinik für Psychiatrie und Psychotherapie, University of Cologne
Cologne, Brescia, Germany
The University Hospital Jena, Department of Psychiatry
Jena, Thuringia, Germany
Ludwig-Maximilians-Universität Munich
Munich, Germany
The University of Hong Kong, Department of Psychiatry
Hong Kong, Hong Kong
University of Pavia
Pavia, Pavia, Italy
Early Psychosis Intervention Programme (EPIP) Clinic, Institute of Mental Health
Singapore, Singapore
Department of Psychiatry, Chonnam National University Hospital & Mindlink
Gwangju, South Korea
Seoul National University College of Medicine
Seoul, South Korea
Instituto de Psiquiatría y Salud Mental Hospital General Universitario Gregorio Marañón
Madrid, Spain
Treatment and Early Intervention in Psychosis Program (TIPP) & Center for Psychiatric Neuroscience (CNP), Department of Psychiatry, Lausanne University Hospital
Lausanne, Switzerland
Forward Thinking Birmingham
Birmingham, United Kingdom
University of Cambridge
Cambridge, United Kingdom
King's College London
London, United Kingdom