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Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Sponsor: Washington University School of Medicine
Summary
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.
Key Details
Gender
All
Age Range
21 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2023-03-07
Completion Date
2027-07-31
Last Updated
2026-03-12
Healthy Volunteers
Not specified
Conditions
Interventions
Electroencephalography (EEG)
High-density EEG will be acquired during resting wakefulness before each ECT session.
Quantitative Measurements of Sleep Microstructure
Overnight sleep EEG will be recorded one day before each ECT session using the DREEM device. The DREEM device allows continuous recording of multichannel EEG.
Locations (1)
Washington University School of Medicine/Barnes-Jewish Hospital
St Louis, Missouri, United States