Clinical Research Directory

Inclusion Criteria: * Single, stroke \> 6 months since onset * Residual hemiparetic gait deficits (e.g., abnormal gait pattern) Exclusion Criteria: * Lesions affecting the brainstem or cerebellum * Other neurological disorders that may interfere with motor function * Unhealed decubiti, persistent infections that may interfere with ability to perform test procedures * Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE\<21)), which could impede the understanding of the purpose of procedures of the study * Botulinum toxin (Botox) treatments to the lower limb within the past 6 months * Pregnant women * Contraindications to transcranial magnetic stimulation (TMS) or ischemic conditioning (IC) (Listed below) TMS General Exclusion Criteria: * Previous adverse reaction to TMS * Skull abnormalities or fractures * Concussion within the last 6 months * Unexplained, recurring headaches * Implanted cardiac pacemaker * Metal implants in the head or face * History of seizures or epilepsy * Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants) * Current pregnancy IC General Exclusion Criteria: * History of thrombosis (i.e., blood clots) including venous thrombosis or deep vein thrombosis (DVT). * Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., open wounds in the leg, bruising, nerve damage, etc.) * Peripheral arterial grafts in the lower extremity * History of uncontrolled hypertension * History of peripheral vascular disease or hematological disease