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Deuterium Metabolic Imaging to Assess Radiotherapy Changes in Glioblastoma Multiforme
Sponsor: University of Aarhus
Summary
This is a feasibility single arm study designed for obtaining early data for optimization and evaluation of the clinical potential for a new MR technique using deuterated glucose. The purpose of the study is to investigate whether this technique is useful in metabolic imaging of glioblastoma multiforme (GBM) and whether radiochemotherapy (RCT) induced changes in the brain metabolism can be detected and might be predictive for treatment response. The study will include 10 patients with histologically verified GBM scheduled for standard RCT. Patients will have MRI scan performed before and within 8 weeks after starting RCT. The scans will include imaging after oral intake of deuterated glucose, so called deuterium metabolic imaging (DMI). Based on this study, the most optimal scanning technique, output variables of highest discriminative power with respect to RCT, and potential predictive markers for response will be selected for further clinical investigation.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
10
Start Date
2023-08-25
Completion Date
2026-12-31
Last Updated
2023-12-07
Healthy Volunteers
No
Conditions
Interventions
Deuterium metabolic imaging
MRI after oral administration of 75g of \[6,6'-2H2\]glucose.
Locations (1)
Aarhus University
Aarhus, Denmark