Inclusion Criteria:
1. Participant must provide informed consent before any study specific activities are performed, must be able and willing to meet all requirements for randomisation, and must adhere to the schedules of activities.
2. Men must be ≥ 21 years of age at the time of signing the ICF. Women must be ≥ 40 years of age at the time of signing the ICF. For female participants, the participant must not be pregnant or lactating and must be of non-childbearing potential, confirmed at screening Visit 1 by one of the following:
1. Postmenopausal, defined as amenorrhea for ≥ 12 months following cessation of all exogenous hormonal treatments, and with luteinizing hormone and follicle stimulating hormone levels in the postmenopausal range.
2. Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy, or bilateral salpingectomy. Tubal ligation is not considered as irreversible surgical sterilization.
3. Participant must have body mass index within the range 18 to 40 kg/m2 inclusive.
4. Participants must have moderate stable PAD (ABI \< 0.7 and/or TBI \< 0.5) with no prior history of lower limb revascularisation or ulcers.
5. On stable medical therapy for type 2 DM for at least 6 weeks prior to screening with no clinically significant dose change and/or new medications in the recent 6 weeks
6. All male participants should refrain from fathering a child or donating sperm during the study and for 190 days following the last dose. Non-sterilised male study participants should be advised to use a condom for all sexual intercourse with a female partner of childbearing potential from Day 1 through the end of the study follow-up period.
Exclusion Criteria:
1. History of any clinically important disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or influence the results or the participant's ability to participate in the study.
2. Uncontrolled Type 1 or Type 2 diabetes defined as haemoglobin A1c (HbA1c) \>10%.
3. Increased risk of bleeding
1. Patients with history or presence of any bleeding disorder.
2. Signs of ongoing bleeding at screening (e.g., identified macroscopic bleeding, low haemoglobin presumed to be caused by bleeding) or high risk for major bleeding in accordance with the Investigator's assessment.
3. . Need for chronic therapeutic anticoagulation therapy anticipated to be required throughout the course of the study (short-term treatment with prophylactic doses of heparin/low molecular weight heparin are allowed).
4. Known severe liver disease (e.g., ascites and/or clinical signs of coagulopathy).
4. History or presence of any of the following:
1. Cancer within 5 years before randomization, except for non-melanoma skin cancer.
2. Alcohol or substance abuse within 6 months before randomization, as judged by the investigator.
3. Known history of hypersensitivity reactions to other biologics, to human IgG preparations, or to any component of MEDI6570, or ongoing severe allergy as judged by the investigator.
4. Patients with active positive results on screening for serum hepatitis B surface antigen, hepatitis C antibody, or HIV.
5. Any clinically important abnormalities in clinical chemistry, haematology, coagulation parameters, as judged by the investigator, including but not limited to:
1. AST \> 2.0 × ULN.
2. ALT \> 2.0 × ULN.
3. TBL \> 1.5 x ULN (unless due to Gilbert's syndrome).
4. Platelet count \< 100,000 platelets/μl.
6. BP values at screening Visit 1:
1. Systolic BP \< 90 mmHg or \> 180 mmHg.
2. Diastolic BP \> 100 mmHg.
3. Participants who are excluded based on elevated BP may be rescreened following adequate treatment.
7. Any clinically important abnormalities in clinical chemistry, haematology, coagulation parameters, or urinalysis results.
8. History of blood dyscrasia, haemostatic disorder, systemic bleeding, or prior trauma that places the subject at a higher risk of bleeding.
9. Receipt of any investigational device or therapy within 6 months or 5 half-lives before screening (whichever is longer). This criterion does NOT apply for inactive, non-replicating COVID-19 vaccines approved by Health Authorities or under emergency use authorization.
10. Planned participation in an additional investigational study of an intervention or biologic before the end of the follow-up period. Participation in observational studies or studies without investigational drugs or devices is allowed.
11. Participants who are legally institutionalised.
12. An employee or close relative of an employee of the sponsor,
