Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years * Patients with structural heart disease * Patients with implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy with defibrillation (CRT-D) * Clinically symptomatic ventricular arrhythmia despite adequate treatment, with episodes of ventricular tachycardia occurring at least 3 times per month * At least one episode of monomorphic ventricular tachycardia recorded during an electrophysiological examination * Recurrent VT despite at least one previous failed attempt at percutaneous ablation or disqualification from this treatment method (eg, patients after percutaneous closure of patent foramen ovale, ventricular septal defect). * Persistent recurrence of VT despite adequate pharmacotherapy. * Informed consent of the patient to participate in the study. Exclusion Criteria: * Premature ventricular contractions * Cardiac damage requiring inotropic treatment * Implantation of left ventricular assist device (LVAD) * Ventricular arrhythmia in the course of channelopathy * Reversible cause of VT * New York Heart Association (NYHA) stage IV heart failure * Myocardial infarction or cardiac surgery in the last 3 months. * Life expectancy less than 6 months * Polymorphic ventricular tachycardia * Pregnancy or breastfeeding * Substrate location that prevents safe radiotherapy (eg due to location relative to critical organs, or dose given during previous radiotherapy treatments). * Evidence of an active systemic, pulmonary or pericardial inflammatory process that has required systemic treatment in the past 6 months (eg disease-modifying drugs, steroids, immunosuppressants). Patients treated for sarcoidosis who are currently in remission on chronic immunosuppressive drugs, without current signs of an acute inflammatory process, may be included in the study. * Active, uncontrolled malignancy and/or chemo/immunotherapy in the past month or planned within the month following radioablation. * Lack of the informed consent