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Exercise to Augment TMS in Those With Treatment Resistant Depression
Sponsor: Butler Hospital
Summary
Given the growing evidence that aerobic increases cortical excitability and promotes neuroplasticity, the scientific premise for its potential priming effect on the brain is strong. Combining AE with rTMS may produce a neural environment optimized for a robust physiological effect of rTMS, thereby leading to improved depression outcomes. With positive findings, this study would provide preliminary support for an innovative, safe and feasible approach for improving outcomes for this significant public health problem.
Official title: Aerobic Exercise to Augment the Plasticity Effect of rTMS in Patients With Treatment-resistant Depression
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2024-02-01
Completion Date
2025-12-31
Last Updated
2025-05-14
Healthy Volunteers
No
Conditions
Interventions
Aerobic Exercise
20 minutes of supervised aerobic exercise on a treadmill prior to each TMS session
Video Watching
20 minutes of watching documentaries or educational videos prior to each TMS session
Locations (1)
Butler Hospital
Providence, Rhode Island, United States