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FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort
Sponsor: Central Hospital, Nancy, France
Summary
The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.
Official title: HÉRITABILITÉ FAMILIALE, INTERACTIONS GÈNE-GÈNE ET GÈNE-ENVIRONNEMENT DANS LE DOMAINE DES MALADIES CARDIOVASCULAIRES ET RENALES. Cinquième Visite de la Cohorte STANISLAS
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
3000
Start Date
2023-07-13
Completion Date
2027-07-13
Last Updated
2023-08-15
Healthy Volunteers
Yes
Interventions
Blood and urine samples
Blood and urine samples
Blood samples
Blood samples
Cardiovascular assessment
Echocardiography, Lung ultrasound, pulse wave velocity, carotid stiffness and thickness, Central and peripheral blood pressure, carotid pulse pressure, abdominal aorta ultrasound, jugular vein ultrasound, liver elastography (Optional).
Dietary intake
Food frequency questionnaires, ''Dutch eating behaviour questionnaire'' and dietary supplement questionnaire
Anthropometric parameters
Measurement of height, weight, abdominal circumference, hip circumference, arm circumference
Hemodynamic parameters
Systolic pressure index measurement
Hemodynamic parameters
Heart rate measurements, blood pressure measurements, orthostatic BP measurements
Hemodynamic parameters
Blood pressure measurements by "unattended BP" monitor over 5 min
Hemodynamic parameters
Electrocardiogram
Assessment of compliance with antihypertensive treatments for treated participants
EVALOBS scale and compliance questionnaire
Ambulatory 24 hours measurment of blood pressure
For the first 100 patients willing to participate
24 hours urinary collection
For the first 100 patients willing to participate. For biobank constitution and measurement of microalbuminuria, creatininuria, osmolarity, natriuresis, kaliuresis, urea, proteinuria and urine dipstick
General questionnaires
Collection of socio-demographic data such as age, level of education, profession, household income, smoking status, physical activity, perception of health, prematurity, height and weight at birth, family and personal history especially cardiovascular (history of stroke, myocardial infarction, heart failure, current pathologies, drugs, tobacco...)
Women specific questionnaire
Women specific questionnaire
Women specific questionnaire
Women specific questionnaire
NYHA dyspnea questionnaire
Determination of NYHA class.
Anxiety questionnaire
Assessment of anxiety
Epworth Sleepiness Scale
sleep quality assessment
A questionnaire on the "perception of the management of cardiovascular risk factors"
Patient's evaluation of cardiovascular risk factors by the health system
A questionnaire on eating behaviors
Assessment of eating behaviors
A questionnaire on eating habits to determine consumer profiles
Assessement of eating habit to create a consumer profile
A questionnaire on food supplements use
Evaluation od food supplements intake
SARS-CoV-2 Infection Questionnaire
SARS-CoV-2 Infection Questionnaire
Instantaneous expired air analysis
Carbon monoxyde analysis in expired air
Capillary sampling
Capillary sampling for pollutant analysis (Optional)
Locations (1)
CHRU de Nancy
Vandœuvre-lès-Nancy, Lorraine, France