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Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Sponsor: Rush University Medical Center
Summary
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.
Official title: A Randomized Controlled Trial of Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
250
Start Date
2023-07-10
Completion Date
2026-12-01
Last Updated
2025-10-20
Healthy Volunteers
No
Conditions
Interventions
Noninvasive ventilation alternating with high flow nasal cannula
A total of 24 hours of prophylactic respiratory support will be provided using NIV alternating with HFNC with total NIV usage of 16 hours and HFNC usage of 8 hours.
High flow nasal cannula
A total of 24 hours of prophylactic respiratory support will be provided using HFNC alone.
Locations (5)
Rush University Medical Center
Chicago, Illinois, United States
Central DuPage Hospital
Winfield, Illinois, United States
McGovern Medical School, The University of Texas Health Science Center
Houston, Texas, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Hospital Civil Fray Antonio Alcalde
Guadalajara, Jalisco, Mexico