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HN-QUEST: A Study of Head and Neck Imaging Biomarkers
Sponsor: University Health Network, Toronto
Summary
This is a multi arm, single center, investigator initiated study to investigate online adaptive radiotherapy and biomarker development in patients with newly diagnosed HNSCC (Head and Neck Squamous Cell Carcinoma) receiving curative therapy. The study will consist of two prospective arms. In Arm 1 up to 100 HNSCC patients receiving (CT)RT (computed tomography-based radiation therapy) will receive up to weekly non-contrast MRI (magnetic resonance imaging) scans during treatment. Arm 2 consists of two cohorts. In cohort A up to 20 healthy volunteers will undergo non-contrast MRI at two time points. In cohort B up to 53 patients planned to receive curative (chemo) radiotherapy for HNSCC will undergo two baseline MRI scans, one MRI in week 2 and week 4, and final MRI scan 6-8 weeks after completion of treatment.
Official title: HN QUEST- Evaluation of Online MRgRT and Repeat Functional Imaging in Patients Undergoing Curative (CT)RT for HN Malignancy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
173
Start Date
2023-07-26
Completion Date
2029-07-01
Last Updated
2026-03-05
Healthy Volunteers
Yes
Conditions
Interventions
MRI
Non-invasive imaging technique that is used to take pictures of organs within the body.
Locations (1)
Princess Margaret Cancer Centre
Toronto, Ontario, Canada