Clinical Research Directory

Inclusion Criteria * Age \>18 years * Good general health (controlled conditions) * Fluent in English * Treatment-planned for single site extraction and bone graft surgery Exclusion criteria * Pregnancy * Site with active infection i.e purulence, abscess formation * Patients experiencing pain pre-operatively * Oral surgery in more than one site/quadrant in the same session * Patients receiving surgery under sedation * Patients with any contraindication for oral bone grafting surgery (e.g., on anticoagulants, medication-related osteonecrosis of the jaw, etc.) * Patients experiencing acute or chronic oral pain due to conditions or previous interventions * Patients with diseases or taking medications that affect hard and soft tissue wound healing such as poorly controlled diabetes, bisphosphonate use, corticosteroid use, chemotherapy, immunosuppressive therapy, etc. * Current or chronic (≥4 weeks) use of anti-inflammatory, analgesic, corticosteroid or sedative medications in the past 6 months * Health conditions that contraindicate the use of NSAIDs, such as stomach ulcers, bleeding disorders, renal disfunction, liver cirrhosis or acute liver disease, etc. * Intake of medications that interact with NSAIDs or whose actions can be affected by NSAIDs, such as anticoagulant/antiplatelet medications, ACE inhibitors, diuretics, etc. * Allergy to ibuprofen, acetaminophen and/or aspirin, and study materials (e.g., sutures, grafts, membranes?). * Patients having 3 or more alcoholic beverages daily * Patients who are planned to undergo heart surgery or had heart surgery less than 6 months prior * Not fluent in English