Clinical Research Directory

Inclusion Criteria: * Hospitalization for acute ST-elevation MI (STEMI) or non ST-elevation MI (NSTEMI) within 365 days prior to screening * Men and women aged ≥18 years who are capable and willing to provide consent * ECG ischemic changes, such as persistent or dynamic ST-segment deviation * Evidence of positive high-sensitive troponin * Confirmation of coronary heart disease aetiology by angiography * Capacity to complete study visits with strict adherence to the protocol assignment * Self-reported average alcohol consumption of between 4 and 28 standard units per week in the 12 months prior to the index hospitalization. Exclusion Criteria: * High alcohol consumption, defined as an average of \>28 alcoholic standard units/week in the 12 months prior to the index hospitalization * Alcohol use disorder (AUDIT score \>20 at screening) * History of alcohol or substance abuse * Naïve to alcohol consumption * Light alcohol consumption (\<4 standard units by week) * Prior severe heart failure (NYHA III-IV) * Severe LV dysfunction at screening (\<30%) * History of gastric ulcer or gastro-intestinal bleeding * Serious chronic liver disease or liver test elevation (\> 3 times upper limit normal range) * Personal history of any colon or liver cancer * Any active malignancy (less than 5 years or ongoing treatment) * Estimated glomerular filtration rate 15 ml/min/1.73m² or end-stage renal disease * Any medication (investigator's discretion) making study participation impractical or precluding required follow-up * History of organ transplant * Participation in another trial testing intervention on similar CV outcomes (investigator's discretion) * Any medical, geographic, or social factor making study participation impractical or precluding required follow-up. * Pregnant, breastfeeding or planning to become pregnant within 12 months.