Clinical Research Directory

Inclusion Criteria: 1. Patients who are fully informed and sign informed consent by themselves or their guardians; 2. Patients receiving first allogeneic hematopoietic stem cell transplantation; 3. Patients with acute graft-versus-host disease of grade II-IV were diagnosed after transplantation; 4. KPS\>60, Estimated survival \>3 months; 5. No serious organ damage: 1. ANC in peripheral blood is greater than 0.5×109/l 2. Creatinine \< 1.5mg/dl 3. Cardiac ejection index \> 55% Exclusion Criteria: 1. Patients with severe brain, heart, kidney or liver dysfunction unrelated to graft-versus host disease; 2. Patients with uncontrollable active infection; 3. Patients with recurrence of primary malignant hematopathy; 4. Expected survival is less than 3 months 5. Patients who have histories of severe allergic reactions 6. Pregnant or lactating women 7. The researcher judges that there are other factors that are not suitable for participating 8. Patients who received donor lymphocyte infusion