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RECRUITING
NCT05922384
NA

Safety and Efficacy Study of KL-7SHRNA Injection Solution in the Treatment of AIDS Patients With Lymphoma

Sponsor: Affiliated Hospital of Guangdong Medical University

View on ClinicalTrials.gov

Summary

This pilot clinical trial studies gene therapy in treating patients with HIV-1 infecetion combined with lymphoma undergoing 7shRNA lentiviral vector transduced CD34+ hematopoietic stem cell transplant. Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. After treatment, CD34+hematopoietic stem cells are mobilized and collected from the patient's peripheral blood. The CD34+stem cells are then isolated and transduced with lenti-7shRNA vector and reinfused to the patient to replace the blood-forming cells that were destroyed by the chemotherapy.

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

3

Start Date

2023-07-05

Completion Date

2026-04-10

Last Updated

2023-06-28

Healthy Volunteers

No

Interventions

DRUG

KL-7SHRNA injection solution

Patients continue to receive HAART throughout treatment until meet the criteria of interruption of HAART.

Locations (1)

Affiliated hospital of Guangdong medical university

Zhanjiang, Guangdong, China