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Safety and Efficacy Study of KL-7SHRNA Injection Solution in the Treatment of AIDS Patients With Lymphoma
Sponsor: Affiliated Hospital of Guangdong Medical University
Summary
This pilot clinical trial studies gene therapy in treating patients with HIV-1 infecetion combined with lymphoma undergoing 7shRNA lentiviral vector transduced CD34+ hematopoietic stem cell transplant. Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. After treatment, CD34+hematopoietic stem cells are mobilized and collected from the patient's peripheral blood. The CD34+stem cells are then isolated and transduced with lenti-7shRNA vector and reinfused to the patient to replace the blood-forming cells that were destroyed by the chemotherapy.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
3
Start Date
2023-07-05
Completion Date
2026-04-10
Last Updated
2023-06-28
Healthy Volunteers
No
Conditions
Interventions
KL-7SHRNA injection solution
Patients continue to receive HAART throughout treatment until meet the criteria of interruption of HAART.
Locations (1)
Affiliated hospital of Guangdong medical university
Zhanjiang, Guangdong, China