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Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions
Sponsor: University Hospital, Bordeaux
Summary
The purpose of this study is to perform an in-depth analysis of the molecular pathways involved in lesions responding to current treatment and lesions not responding to current treatment
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2024-04-10
Completion Date
2025-10-09
Last Updated
2024-04-19
Healthy Volunteers
No
Conditions
Interventions
SKIN SAMPLES
At baseline: one 4 mm Ø skin biopsies: on forearms (excluding skin folds): fresh At month 3 and month 6: Two 4 mm Ø skin biopsies will be performed on the same lesion selected at baseline (one on a repigmented area, one on a non-responded area): fresh Fresh Skin biopsies will be analyzed the same day using Single-cell RNA sequencing (scRNAseq).
BLOOD SAMPLES
Blood samples will be taken (30 mL) at week 0, week 12, week 24 for the measurement of pro-inflammatory cytokines and chemokines ligands in blood sera.
narrowband UVB
narrowband UVB (Nb-UVB) 2 times a week
Systemic Steroids
Oral minipuls of systemic steroids (Medrol 16mg twice a week) for 24 weeks
Locations (1)
University Hospital of Bordeaux - St André Hospital
Bordeaux, France