Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT05927272
NA

Deciphering the Vitiligo Transcriptomic Signature Between Repigmented and Non Repigmented Lesions

Sponsor: University Hospital, Bordeaux

View on ClinicalTrials.gov

Summary

The purpose of this study is to perform an in-depth analysis of the molecular pathways involved in lesions responding to current treatment and lesions not responding to current treatment

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

10

Start Date

2024-04-10

Completion Date

2025-10-09

Last Updated

2024-04-19

Healthy Volunteers

No

Conditions

Interventions

PROCEDURE

SKIN SAMPLES

At baseline: one 4 mm Ø skin biopsies: on forearms (excluding skin folds): fresh At month 3 and month 6: Two 4 mm Ø skin biopsies will be performed on the same lesion selected at baseline (one on a repigmented area, one on a non-responded area): fresh Fresh Skin biopsies will be analyzed the same day using Single-cell RNA sequencing (scRNAseq).

PROCEDURE

BLOOD SAMPLES

Blood samples will be taken (30 mL) at week 0, week 12, week 24 for the measurement of pro-inflammatory cytokines and chemokines ligands in blood sera.

DEVICE

narrowband UVB

narrowband UVB (Nb-UVB) 2 times a week

DRUG

Systemic Steroids

Oral minipuls of systemic steroids (Medrol 16mg twice a week) for 24 weeks

Locations (1)

University Hospital of Bordeaux - St André Hospital

Bordeaux, France