Clinical Research Directory

Inclusion Criteria: * Age between 18 and 45 years * Male or female * Right-handed * In good general health * Women of childbearing capacity: use of effective method of birth control Exclusion Criteria: * Current or diagnosis within past six months of an DSM-V Axis I or Axis II disorder (self-reported) * CES-D score of 20 or higher (indicating significant current depression symptoms) * Current or past six month use of prescription medications indicated for psychiatric conditions (e.g.,depression, anxiety) * Current serious medical illness (self-reported) * Head injury resulting in loss of consciousness * For participants age \> 59 years, a total scaled score \< 8 on the Dementia Rating Scale-2. * A clinically-defined neurological disorder including, but not limited to: * Any condition likely to be associated with increased intracranial pressure * Space occupying brain lesion * History of stroke * Transient ischemic attack within two years * Cerebral aneurysm * Dementia * Mini Mental Status Exam (MMSE) score of \<24 * Parkinson's disease * Huntington's disease * Multiple sclerosis * Presence of cochlear implants or other implanted electronic devices or non-removable metal (e.g., non-removable piercing, IUD) * History of an eye injury involving metal. Participants who worked with metal may be allowed to participate on a case-by-case basis with prior written approval from BIAC. * Claustrophobia or unwillingness to tolerate the confinement associated with being in the MRI scanner. * Weight of more than 250 pounds