Clinical Research Directory
Browse clinical research sites, groups, and studies.
TMS + Exposure Therapy for Pediatric OCD
Sponsor: Bradley Hospital
Summary
The goal of this clinical trial is to compare different forms of transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive Disorder (OCD). Researchers will compare three groups: ERP with one of two different active ("real") forms of TMS vs. ERP with sham ("fake") TMS. The main questions this study aims to answer are: 1) whether TMS normalizes functioning in brain circuits that contribute to compulsive behavior, and 2) whether TMS reduces compulsions during ERP. Participants will: * Complete clinical interviews, questionnaires, and computerized tasks * Complete two MRIs (brain scans) * Receive daily TMS followed by ERP for two weeks (10 sessions)
Official title: Transcranial Magnetic Stimulation to Augment Exposure and Response Prevention for Pediatric OCD
Key Details
Gender
All
Age Range
12 Years - 21 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-03-20
Completion Date
2026-07-31
Last Updated
2026-04-08
Healthy Volunteers
No
Conditions
Interventions
Transcranial Magnetic Stimulation: intermittent theta burst to dorsolateral prefrontal cortex
TMS will be delivered over the dorsolateral prefrontal cortex (dlPFC) using an intermittent bursting pattern
Exposure with Response Prevention
ERP will be delivered daily, immediately following TMS
Transcranial Magnetic Stimulation: Sham
Sham stimulation will use the Magstim sham air-cooled coil, which produces auditory signals and appears identical to an active coil but contains a mu-metal shield that diverts the majority of the magnetic flux such that a minimal (\<3%) magnetic field is delivered to the cortex
Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area
TMS will be delivered over the pre supplementary motor area (preSMA) using a continuous bursting pattern
Locations (2)
University of Minnesota
Minneapolis, Minnesota, United States
Emma Pendleton Bradley Hospital
Riverside, Rhode Island, United States