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ACTIVE NOT RECRUITING
NCT05931913
NA

TMS + Exposure Therapy for Pediatric OCD

Sponsor: Bradley Hospital

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to compare different forms of transcranial magnetic stimulation (TMS) for improving the outcomes of Exposure with Response Prevention (ERP) in youth and young adults with Obsessive-Compulsive Disorder (OCD). Researchers will compare three groups: ERP with one of two different active ("real") forms of TMS vs. ERP with sham ("fake") TMS. The main questions this study aims to answer are: 1) whether TMS normalizes functioning in brain circuits that contribute to compulsive behavior, and 2) whether TMS reduces compulsions during ERP. Participants will: * Complete clinical interviews, questionnaires, and computerized tasks * Complete two MRIs (brain scans) * Receive daily TMS followed by ERP for two weeks (10 sessions)

Official title: Transcranial Magnetic Stimulation to Augment Exposure and Response Prevention for Pediatric OCD

Key Details

Gender

All

Age Range

12 Years - 21 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2024-03-20

Completion Date

2026-07-31

Last Updated

2026-04-08

Healthy Volunteers

No

Interventions

DEVICE

Transcranial Magnetic Stimulation: intermittent theta burst to dorsolateral prefrontal cortex

TMS will be delivered over the dorsolateral prefrontal cortex (dlPFC) using an intermittent bursting pattern

BEHAVIORAL

Exposure with Response Prevention

ERP will be delivered daily, immediately following TMS

DEVICE

Transcranial Magnetic Stimulation: Sham

Sham stimulation will use the Magstim sham air-cooled coil, which produces auditory signals and appears identical to an active coil but contains a mu-metal shield that diverts the majority of the magnetic flux such that a minimal (\<3%) magnetic field is delivered to the cortex

DEVICE

Transcranial Magnetic Stimulation: continuous theta burst to pre supplementary motor area

TMS will be delivered over the pre supplementary motor area (preSMA) using a continuous bursting pattern

Locations (2)

University of Minnesota

Minneapolis, Minnesota, United States

Emma Pendleton Bradley Hospital

Riverside, Rhode Island, United States