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Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
Sponsor: Vanderbilt University Medical Center
Summary
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2023-07-06
Completion Date
2026-05-30
Last Updated
2025-12-15
Healthy Volunteers
No
Conditions
Interventions
Neural recordings and stimulation
Neural activities from the dorsolateral prefrontal cortex and implanted DBS generator will be recorded, during resting and working memory tasks, and with the DBS target turned on and off.
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States